Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Practice Guideline
. 2014 May;95(5):499-500.
doi: 10.1038/clpt.2014.38. Epub 2014 Feb 21.

Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing: 2014 update

M A Martin  1 , J M Hoffman  2 , R R Freimuth  3 , T E Klein  4 , B J Dong  5 , M Pirmohamed  6 , J K Hicks  7 , M R Wilkinson  2 , D W Haas  8 , D L Kroetz  1 ; Clinical Pharmacogenetics Implementation Consortium
Affiliations
Practice Guideline

Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing: 2014 update

M A Martin et al. Clin Pharmacol Ther. 2014 May.

Abstract

The Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for HLA-B Genotype and Abacavir Dosing were originally published in April 2012. We reviewed recent literature and concluded that none of the evidence would change the therapeutic recommendations in the original guideline; therefore, the original publication remains clinically current. However, we have updated the Supplementary Material online and included additional resources for applying CPIC guidelines to the electronic health record. Up-to-date information can be found at PharmGKB (http://www.pharmgkb.org).

PubMed Disclaimer

References

    1. Relling M.V., Klein T.E. CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network. Clin. Pharmacol. Ther. 2011;89:464–467. - PMC - PubMed
    1. Martin M.A., Klein T.E., Dong B.J., Pirmohamed M., Haas D.W., Kroetz D.L. Clinical Pharmacogenetics Implementation Consortium Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing. Clin. Pharmacol. Ther. 2012;91:734–738. - PMC - PubMed
    1. Schnyder B., Adam J., Rauch A., Thurnheer M.C., Pichler W.J. HLA-B*57:01(+) abacavir-naive individuals have specific T cells but no patch test reactivity. J. Allergy Clin. Immunol. 2013;132:756–758. - PubMed
    1. Shuldiner A.R., et al. Pharmacogenomics Research Network Translational Pharmacogenetics Program Group The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation. Clin. Pharmacol. Ther. 2013;94:207–210. - PMC - PubMed
    1. Wilke R.A., et al. The emerging role of electronic medical records in pharmacogenomics. Clin. Pharmacol. Ther. 2011;89:379–386. - PMC - PubMed

Publication types