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. 2014 Mar 12;136(10):3744-7.
doi: 10.1021/ja412706d. Epub 2014 Mar 3.

Double C(sp3)-H bond functionalization mediated by sequential hydride shift/cyclization process: diastereoselective construction of polyheterocycles

Keiji Mori  1 , Kazuki Kurihara, Shinnosuke Yabe, Masahiro Yamanaka, Takahiko Akiyama
Affiliations

Double C(sp3)-H bond functionalization mediated by sequential hydride shift/cyclization process: diastereoselective construction of polyheterocycles

Keiji Mori et al. J Am Chem Soc. .

Abstract

Described herein are two novel types of double C(sp(3))-H bond functionalizations triggered by a sequential hydride shift/cyclization process: (1) construction of a bicyclo[3.2.2]nonane skeleton by a [1,6]- and [1,5]-hydride shift sequence and (2) sequential [1,4]- and [1,5]-hydride shift mediated construction of a linear tricyclic skeleton.

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