Potential for improved glycemic control with dietary Momordica charantia in patients with insulin resistance and pre-diabetes
- PMID: 24566057
- PMCID: PMC3945602
- DOI: 10.3390/ijerph110202328
Potential for improved glycemic control with dietary Momordica charantia in patients with insulin resistance and pre-diabetes
Abstract
Bitter Melon (Momordica charantia) is a widely used traditional remedy for hyperglycemia. While the medicinal properties of this plant have been studied extensively using in vitro and animal models, the clinical efficacy and safety in humans is largely unknown. This review discusses the benefits and limitations of bitter melon supplementation in the context of epidemic levels of insulin resistance and pre-diabetes throughout the world.
Similar articles
-
Safety and efficacy of Momordica charantia Linnaeus in pre-diabetes and type 2 diabetes mellitus patients: a systematic review and meta-analysis protocol.Syst Rev. 2018 Nov 15;7(1):192. doi: 10.1186/s13643-018-0847-x. Syst Rev. 2018. PMID: 30442186 Free PMC article.
-
Bitter gourd (Momordica charantia L.) supplementation for twelve weeks improves biomarkers of glucose homeostasis in a prediabetic population.J Ethnopharmacol. 2025 May 12;347:119756. doi: 10.1016/j.jep.2025.119756. Epub 2025 Apr 6. J Ethnopharmacol. 2025. PMID: 40199408 Clinical Trial.
-
Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus.Complement Ther Med. 2020 Aug;52:102524. doi: 10.1016/j.ctim.2020.102524. Epub 2020 Jul 22. Complement Ther Med. 2020. PMID: 32951763 Clinical Trial.
-
Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis.J Ethnopharmacol. 2019 Mar 1;231:311-324. doi: 10.1016/j.jep.2018.10.033. Epub 2018 Oct 30. J Ethnopharmacol. 2019. PMID: 30385422
-
Bitter melon (Momordica charantia): a review of efficacy and safety.Am J Health Syst Pharm. 2003 Feb 15;60(4):356-9. doi: 10.1093/ajhp/60.4.356. Am J Health Syst Pharm. 2003. PMID: 12625217 Review.
Cited by
-
Novel nutraceutic therapies for the treatment of metabolic syndrome.World J Diabetes. 2016 Apr 10;7(7):142-52. doi: 10.4239/wjd.v7.i7.142. World J Diabetes. 2016. PMID: 27076875 Free PMC article. Review.
-
Phytotherapy in the Management of Diabetes: A Review.Molecules. 2018 Jan 4;23(1):105. doi: 10.3390/molecules23010105. Molecules. 2018. PMID: 29300317 Free PMC article. Review.
-
Determination of cucurbitacin E in some selected herbs of ayurvedic importance through RP-HPLC.J Ayurveda Integr Med. 2020 Jul-Sep;11(3):287-293. doi: 10.1016/j.jaim.2019.01.002. Epub 2019 Apr 10. J Ayurveda Integr Med. 2020. PMID: 30981623 Free PMC article.
-
Bitter Melon Extract Yields Multiple Effects on Intestinal Epithelial Cells and Likely Contributes to Anti-diabetic Functions.Int J Med Sci. 2021 Feb 24;18(8):1848-1856. doi: 10.7150/ijms.55866. eCollection 2021. Int J Med Sci. 2021. PMID: 33746602 Free PMC article.
-
Nutraceuticals and Supplements in Management of Prediabetes and Diabetes.Nutrients. 2024 Dec 24;17(1):14. doi: 10.3390/nu17010014. Nutrients. 2024. PMID: 39796448 Free PMC article.
References
-
- Center for Disease Control and Prevention (CDC) National Diabetes Fact Sheet. 2011. [(accessed on 14 December 2013)]. Available online: www.cdc.gov/diabetes/pubs/pdf/ndfs_2011.pdf.
-
- Garber A.J., Abrahamson M.J., Barzilay J.I., Blonde L., Bloomgarden Z.T., Bush M.A., Dagogo-Jack S., Davidson M.B., Einhorn D., Garvey W.T., et al. American Association of Clinical Endocrinologists’ comprehensive diabetes management algorithm 2013 consensus statement—Executive summary. Endocr. Pract. 2013;19:536–557. doi: 10.4158/EP13176.CS. - DOI - PMC - PubMed
-
- Handelsman Y., Mechanick J.I., Blonde L., Grunberger G., Bloomgarden Z.T., Bray G.A., Dagogo-Jack S., Davidson J.A., Einhorn D., Ganda O., et al. AACE task force for developing diabetes comprehensive care plan. American Association of Clinical Endocrinologists medical guidelines for clinical practice for developing a diabetes mellitus comprehensive care plan. Endocr. Pract. 2011;17(Suppl 2):1–53. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical