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Comment
. 2014 May;10(5):253-5.
doi: 10.1038/nrendo.2014.18. Epub 2014 Feb 25.

Diabetes. Solving human β-cell development--what does the mouse say?

Alexandra E Folias  1 , Matthias Hebrok  1
Affiliations
Comment

Diabetes. Solving human β-cell development--what does the mouse say?

Alexandra E Folias et al. Nat Rev Endocrinol. 2014 May.

Abstract

A genetic analysis of patients with permanent neonatal diabetes mellitus has revealed functional conservation of transcription factors critical for β-cell development in both mouse and man. This finding supports the use of mice for modelling human disease but also highlights the need for additional human-specific studies of β-cell function.

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References

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