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. 2014 Jan;66(1):23-7.
doi: 10.4097/kjae.2014.66.1.23. Epub 2014 Jan 28.

Effect of pretreatment with palonosetron on withdrawal movement associated with rocuronium injection

Kwangrae Cho  1 , Seoung Hun Lee  1 , Wonjin Lee  1 , Byung-Kwan Chu  1 , Myoung-Hun Kim  1 , Se Hun Lim  1 , Kun Moo Lee  1
Affiliations

Effect of pretreatment with palonosetron on withdrawal movement associated with rocuronium injection

Kwangrae Cho et al. Korean J Anesthesiol. 2014 Jan.

Abstract

Background: The main disadvantage of rocuronium is the pain associated with vascular injection. We evaluated the efficacy of palonosetron for reducing pain after rocuronium injection.

Methods: EIGHTY PATIENTS SCHEDULED FOR ELECTIVE SURGERY WERE RANDOMLY DIVIDED INTO TWO GROUPS: Group C (normal saline 1.5 ml, n = 40) and Group P (palonosetron 0.075 mg, n = 40). Anesthesia was induced with thiopental 5 mg/kg and the test drug was injected over 10 seconds. Thirty seconds after the injection of the test drug, rocuronium 0.6 mg/kg was injected over 30 seconds and the response was recorded. Injection pain was graded using a 4-point scale. The grade was 0 points for no movement, 1 point for wrist movement, 2 points for elbow or shoulder movement, and 3 points for whole body movement. Mean arterial pressure and heart rate were recorded on arrival in the operating room and before and 30 seconds after rocuronim injection.

Results: There was no significant difference in the grade 1 response between the two groups; however, the grade 2 and 3 responses in Group P were 5 (12.5%) and 4 (10%), respectively, which were significantly lower than in Group C, with 13 (32.5%) responses for each grade. There were no significant differences in hemodynamic changes within each group. However, the difference in mean arterial pressure before and after the injection of rocuronium was significantly larger in Group C compared to Group P.

Conclusions: Pretreatment with palonosetron 0.075 mg reduced the incidence and severity of withdrawal movement after rocuronium administration.

Keywords: Injections; Pain; Palonosetron; Rocuronium.

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References

    1. Huizinga AC, Vandenbrom RH, Wierda JM, Hommes FD, Hennis PJ. Intubating conditions and onset of neuromuscular block of rocuronium (Org 9426); a comparison with suxamethonium. Acta Anaesthesiol Scand. 1992;36:463–468. - PubMed
    1. Mayer M, Doenicke A, Hofmann A, Peter K. Onset and recovery of rocuronium (Org9426) and vecuronium under enflurane anesthesia. Br J Anaesth. 1992;69:511–512. - PubMed
    1. Steegers MA, Robertson EN. Pain on injection of rocuronium bromide. Anesth Analg. 1996;83:203. - PubMed
    1. Borgeat A, Kwiatkowski D. Spontaneous movements associated with rocuronium: is pain on injection the cause? Br J Anaesth. 1997;79:382–383. - PubMed
    1. Lui JT, Huang SJ, Yang CY, Hsu JC, Lui PW. Rocuronium induced generalized spontaneous movements cause pulmonary aspiration. Chang Gung Med J. 2002;25:617–620. - PubMed

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