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. 2014 Apr 4;50(26):3516-8.
doi: 10.1039/c3cc49114e. Epub 2014 Feb 24.

Profiling of RNA modifications by multiplexed stable isotope labelling

Stefanie Kellner  1 , Jennifer Neumann, David Rosenkranz, Svetlana Lebedeva, René F Ketting, Hans Zischler, Dirk Schneider, Mark Helm
Affiliations

Profiling of RNA modifications by multiplexed stable isotope labelling

Stefanie Kellner et al. Chem Commun (Camb). .

Abstract

The combination of (15)N/(13)C stable isotope labelling (SIL) and LC-MS/MS revealed a total of 52 modifications in RNA from E. coli and yeast, including 10 previously undescribed modifications. Two modifications, N-ribosylnicotinamide and 2-methylthioadenosine, were newly detected in species hitherto thought not to contain these modifications.

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