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. 2014 Feb 26;6(1):26.
doi: 10.1186/1758-5996-6-26.

Major components of metabolic syndrome and adiponectin levels: a cross-sectional study

Anize D von Frankenberg  1 , Filipe V do Nascimento, Lucas Eduardo Gatelli, Bárbara L Nedel, Sheila P Garcia, Carolina Sv de Oliveira, Pedro Saddi-Rosa, André F Reis, Luis H Canani, Fernando Gerchman
Affiliations

Major components of metabolic syndrome and adiponectin levels: a cross-sectional study

Anize D von Frankenberg et al. Diabetol Metab Syndr. .

Abstract

Background: Adiponectin is a major regulator of glucose and lipid homeostasis by its insulin sensitizer properties. Since decreased insulin sensitivity is linked to metabolic syndrome (MS), decreased adiponectin levels may be related to its development. The purpose of the study was to investigate the relationship between adiponectin levels and MS.

Methods: Firstly, we cross-sectionally examined subjects with or without MS submitted to an oral glucose tolerance test at Hospital de Clínicas de Porto Alegre (n = 172). A replication analysis was performed in subjects (n = 422) undergoing cardiac angiography at Hospital São Paulo. Subchronic inflammation (US-CRP), coagulation marker (fibrinogen), insulin sensitivity and resistance (Matsuda ISI and HOMA-IR) were estimated. Plasma total and high molecular weight (HMW) adiponectin were measured.

Results: Total and HMW adiponectin levels were lower in MS subjects (P < 0.05). Total adiponectin levels were lower in the presence of high waist circumference, low HDL-cholesterol and elevated triglyceride criteria in both samples and by elevated blood pressure and glucose criteria in Porto Alegre. HMW adiponectin levels were lower in the presence of low HDL-cholesterol, elevated triglycerides, and glucose criteria. Total adiponectin levels were positively related with HDL-cholesterol and ISI Matsuda, negatively related with waist circumference, glucose, triglycerides, HOMA-IR, and US-CRP and not related with blood pressure. While adjusting for sex and age, increased adiponectin levels remained associated with a reduced prevalence ratio for MS in both cohorts (P = 0.001).

Conclusions: Adiponectin levels decreased with increasing number of MS criteria, and it is in part determined by its relationship with HDL, triglycerides and abdominal adiposity.

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Figures

Figure 1
Figure 1
Adiponectin levels according to the presence of metabolic syndrome (MS). Comparison by independent T test (A). Adiponectin levels according to the number of components of MS. Comparison by ANOVA(B).
Figure 2
Figure 2
Relationship between adiponectin levels and metabolic syndrome criteria. DBP = diastolic blood pressure; SBP = systolic blood pressure.
See this image and copyright information in PMC

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