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Review
. 2015 Jan 28;356(2 Pt A):211-6.
doi: 10.1016/j.canlet.2014.02.019. Epub 2014 Feb 22.

Acetate/acetyl-CoA metabolism associated with cancer fatty acid synthesis: overview and application

Yukie Yoshii  1 , Takako Furukawa  2 , Tsuneo Saga  2 , Yasuhisa Fujibayashi  2
Affiliations
Review

Acetate/acetyl-CoA metabolism associated with cancer fatty acid synthesis: overview and application

Yukie Yoshii et al. Cancer Lett. .

Abstract

Understanding cancer-specific metabolism is important for identifying novel targets for cancer diagnosis and therapy. Induced acetate/acetyl CoA metabolism is a notable feature that is related to fatty acid synthesis supporting tumor growth. In this review, we focused on the recent findings related to cancer acetate/acetyl CoA metabolism. We also introduce [1-¹¹C]acetate positron emission tomography (PET), which is a useful tool to visualize up-regulation of acetate/acetyl CoA metabolism in cancer, and discuss the utility of [1-¹¹C]acetate PET in cancer diagnosis and its application to personalized medicine.

Keywords: Acetate; Acetyl CoA; Fatty acid; Metabolism; Positron emission tomography.

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