Stem cell fate regulation by dynein motor protein Lis1
- PMID: 24569235
- DOI: 10.1038/ng.2902
Stem cell fate regulation by dynein motor protein Lis1
Abstract
Cell fate regulation is a central component of maintaining tissue homeostasis, yet the mechanisms instructing cell division diversity in tissue-specific stem cells have not been well understood. A new study uncovers a central role for microtubule motor-regulating protein Lis1 in hematopoietic stem cell fate determination and in leukemogenesis.
Comment on
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Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia.Nat Genet. 2014 Mar;46(3):245-52. doi: 10.1038/ng.2889. Epub 2014 Feb 2. Nat Genet. 2014. PMID: 24487275 Free PMC article.
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