Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013;9(3):241-5.
doi: 10.5114/pwki.2013.37502. Epub 2013 Sep 16.

Increased mean platelet volume is associated with coronary artery ectasia

Serafettin Demir  1 , Mustafa Kemal Avsar  2 , Zeynep Karakaya  1 , Murat Selcuk  3 , Ayd N Rodi Tosu  3 , Gulcan Abal  4 , Eda Tokuccu  4 , Mesut Demir  5
Affiliations

Increased mean platelet volume is associated with coronary artery ectasia

Serafettin Demir et al. Postepy Kardiol Interwencyjnej. 2013.

Abstract

Aim: The present study was designed to investigate mean platelet volume (MPV) values in coronary artery ectasia (CAE) patients in comparison with individuals with coronary artery disease and normal coronary angiograms.

Material and methods: Patients with stable angina pectoris and scheduled for angiography were included in the study. Those with isolated coronary ectasia were evaluated in the coronary angiography. Mean platelet volume was measured in 126 patients (mean age: 57.2 ±11.3 years) with isolated CAE, 126 patients (mean age: 56.3 ±10.4 years) with coronary artery disease (CAD) and 122 control subjects (mean age: 58.1 ±11.1 years). Coronary artery ectasia was defined as lack of stenotic lesion, on visual assessment, of the coronary arteries with a luminal dilatation 1.5-fold or more of the adjacent normal coronary segments. Mean platelet volume values were recorded in all patients. Ectasia severity was evaluated and categorized in accordance with the Markis categorization.

Results: A significant difference with respect to age, sex, hypertension, diabetes mellitus, and cigarette use between the study groups was not found (p > 0.05). Mean platelet volume was significantly higher in patients with CAE and CAD than in the control group (9.8 ±3.8 fl and 9.7 ±3.9 fl vs. 8.8 ±3.3 fl, p < 0.001). There were no statistically significant differences between CAE and CAD groups. When type I and type IV subgroups were compared in patients with coronary artery ectasia, MPV was detected as statistically high in the type I subgroup (p = 0.026).

Conclusions: It was shown that patients with CAE and CAD have higher MPVs than subjects with normal coronary angiograms. Moreover, it was detected that in coronary artery ectasias, the increase in MPV is related to both the atherosclerotic process and severity of the disease.

Keywords: coronary angiography; coronary artery ectasia; mean platelet volume.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Mean platelet volumes (MPV) in the subgroups of patients with CAE
See this image and copyright information in PMC

References

    1. Hartnell GG, Parnell BM, Pridie RB. Coronary artery ectasia: its prevalence and clinical significance in 4993 patients. Br Heart J. 1985;54:392–395. - PMC - PubMed
    1. Falsetti HL, Carrol RJ. Coronary artery aneurysm. A review of the literature with a report of 11 new cases. Chest. 1976;69:630–636. - PubMed
    1. Befeler B, Aranda MJ, Embi A, et al. Coronary artery aneurysms: study of the etiology, clinical course and effect on left ventricular function and prognosis. Am J Med. 1977;62:597–607. - PubMed
    1. Kruger D, Stierle U, Herrmann G, et al. Exercise-induced myocardial ischemia in isolated coronary artery ectasias and aneurysms (“dilated coronopathy”) J Am Coll Cardiol. 1999;34:1461–1470. - PubMed
    1. Mattern AL, Baker WP, McHale JJ, Lee DE. Congenital coronary aneurysms with angina pectoris and myocardial infarction treated with saphenous vein bypass graft. Am J Cardiol. 1972;30:906–909. - PubMed

LinkOut - more resources