Heat stress in the presence of low RNA polymerase activity increases chromosome copy number of Escherichia coli
- PMID: 2457148
- DOI: 10.1007/BF00334685
Heat stress in the presence of low RNA polymerase activity increases chromosome copy number of Escherichia coli
Abstract
A temperature shift-up accompanied by a reduction in RNA polymerase activity in Escherichia coli causes an increased rate of initiation leading to a 1.7- to 2.2-fold increase in chromosome copy number. A temperature shift-up without a reduction in polymerase activity induces only a transient non-scheduled initiation of chromosome replication caused by heat shock with no detectable effect on chromosome copy number.
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