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. 1988 May;212(2):203-6.
doi: 10.1007/BF00334685.

Heat stress in the presence of low RNA polymerase activity increases chromosome copy number of Escherichia coli

E C Guzman  1 , A Jimenez-Sanchez, E Orr, R H Pritchard
Affiliations

Heat stress in the presence of low RNA polymerase activity increases chromosome copy number of Escherichia coli

E C Guzman et al. Mol Gen Genet. 1988 May.

Abstract

A temperature shift-up accompanied by a reduction in RNA polymerase activity in Escherichia coli causes an increased rate of initiation leading to a 1.7- to 2.2-fold increase in chromosome copy number. A temperature shift-up without a reduction in polymerase activity induces only a transient non-scheduled initiation of chromosome replication caused by heat shock with no detectable effect on chromosome copy number.

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References

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