doi: 10.1038/334499a0.
Regulation of calcium influx by second messengers in rat mast cells
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- PMID: 2457169
- DOI: 10.1038/334499a0
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Regulation of calcium influx by second messengers in rat mast cells
Nature.
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Abstract
Biphasic increases in the free intracellular calcium concentration, consisting of a large initial transient followed by a sustained elevation, are frequently observed in non-excitable cells following stimulation. In rat peritoneal mast cells a cAMP- and Ca-activated chloride current can interact with IP3-dependent calcium influx to provide the sustained elevation of intracellular Ca concentration following transient IP3-induced release of calcium from intracellular stores. This novel combination of second messenger systems provides a flexible means to modulate calcium-dependent processes such as exocytosis.
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