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Editorial
. 2014 Feb 26;3(1):e000769.
doi: 10.1161/JAHA.113.000769.

Endothelial KLF4: crippling vascular injury?

Derin Tugal  1 , Mukesh K Jain, Daniel I Simon
Affiliations
Editorial

Endothelial KLF4: crippling vascular injury?

Derin Tugal et al. J Am Heart Assoc. .
No abstract available

Keywords: Editorials; Krüppel‐like transcription factor; endothelium; vascular injury.

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Figures

Figure 1.
Figure 1.
Diametric relationship of KLF4 and NF‐κB affects vascular endothelial health. Schematic diagram representing antithetical expression of KLF4 and NF‐κB in endothelial cells. A, KLF4 presence and diminished NF‐κB activity promotes vascular integrity. B, KLF4 absence and enhanced NF‐κB activity facilitate injury‐mediated vascular disease associated with inflammatory cell recruitment and neointimal hyperplasia. EC indicates endothelial cell; EEL, external elastic lamina; IEL, internal elastic lamina; KLF4, Krüppel‐like factor 4; NF‐κB, nuclear factor kappa B; SMC, smooth muscle cell.
See this image and copyright information in PMC

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References

    1. Gloor H. Schädigungsmuster eines Letalfaktors (Kr) von Drosophila melanogaster. Arch Julius Klaus Stift. 1950; 25:38-44
    1. Yoshida T, Yamashita M, Horimai C, Hayashi M. Deletion of Krüppel‐like factor 4 in endothelial and hematopoietic cells enhances neointimal formation following vascular injury. J Am Heart Assoc. 2014; 3:e00062210.1161/JAHA.113.000622 - PMC - PubMed
    1. Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Investig. 1973; 52:2745-2756 - PMC - PubMed
    1. Gimbrone MA, Jr, Cotran RS, Folkman J. Human vascular endothelial cells in culture. Growth and DNA synthesis. J Cell Biol. 1974; 60:673-684 - PMC - PubMed
    1. Gimbrone MA, Jr, Topper JN, Nagel T, Anderson KR, Garcia‐Cardena G. Endothelial dysfunction, hemodynamic forces, and atherogenesis. Ann N Y Acad Sci. 2000; 902:230-239 - PubMed

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