doi: 10.1126/science.2457254.
Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells
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- PMID: 2457254
- DOI: 10.1126/science.2457254
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Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells
Science.
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Abstract
A tenfold increase in phospholipase C activity specific for phosphatidylinositol 4,5-bisphosphate (PIP2) was immunopurified from extracts of A-431 epidermoid carcinoma cells stimulated with epidermal growth factor. This finding suggests a biochemical link between growth factor-stimulated tyrosine kinase activity and PIP2 hydrolysis.
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