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. 1988 Aug 19;241(4868):968-70.
doi: 10.1126/science.2457254.

Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells

M I Wahl  1 , T O Daniel, G Carpenter
Affiliations

Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells

M I Wahl et al. Science. .

Abstract

A tenfold increase in phospholipase C activity specific for phosphatidylinositol 4,5-bisphosphate (PIP2) was immunopurified from extracts of A-431 epidermoid carcinoma cells stimulated with epidermal growth factor. This finding suggests a biochemical link between growth factor-stimulated tyrosine kinase activity and PIP2 hydrolysis.

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