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Meta-Analysis
. 2014 Feb 27:4:4207.
doi: 10.1038/srep04207.

The angiotensinogen gene polymorphism is associated with heart failure among Asians

Wen-long Jiang  1 , Hui-wei He  2 , Zhi-jian Yang  3
Affiliations
Meta-Analysis

The angiotensinogen gene polymorphism is associated with heart failure among Asians

Wen-long Jiang et al. Sci Rep. .

Abstract

The angiotensinogen (AGT) gene M235T polymorphism has been suggested to be linked to risk of heart failure (HF). However, association studies on the M235T polymorphism and HF risk have shown conflicting results. PubMed and China Biology Medicine (CBM) databases were systematically searched to identify relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. A total of 1,281 HF cases and 1,376 controls were included in the analysis. The pooled data showed that there was no significant associations between the AGT M235T polymorphism and HF risk for TT vs. MM (OR = 1.17, 95%CI = 0.62-2.19, P = 0.635), MT vs. MM (OR = 0.97, 95%CI = 0.77-1.22, P = 0.776), MT/TT vs. MM (OR = 1.07, 95%CI = 0.67-1.69, P = 0.781), and TT vs. MM/MT (OR = 1.23, 95%CI = 0.86-1.76, P = 0.259). In contrast, in the HF subgroup analysis by ethnicity, the AGT M235T polymorphism had a decreased risk of HF among Asians (MT vs. MM, OR = 0.39, 95%CI = 0.17-0.92, P = 0.032). Our results suggest that the AGT M235T polymorphism is a low-penetrant risk factor for the development of HF among Asians.

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Figures

Figure 1
Figure 1. The flow chart of the included studies.
Figure 2
Figure 2. Forest plot of heart failure risk associated with the AGT M235T (MT vs. MM) among Asians and Europeans.
The squares and horizontal lines correspond to the study-specific OR and 95% CI.
Figure 3
Figure 3. Begg's funnel plot of AGT M235T polymorphism (MT vs. MM) and heart failure risk.
See this image and copyright information in PMC

References

    1. Ju H., Scammel-La Fleur T. & Dixon I. M. Altered mRNA abundance of calcium transport genes in cardiac myocytes induced by angiotensin II. J Mol Cell Cardiol 28, 1119–28 (1996). - PubMed
    1. Kolovou G. D. & Mavrogeni S. Genetics of Human Hypertension, the Role of Angiotensinogen. Should It be One of the Drug Target Genes? Angiology (2013). Epub ahead of print. - PubMed
    1. van Kats J. P., Methot D., Paradis P., Silversides D. W. & Reudelhuber T. L. Use of a biological peptide pump to study chronic peptide hormone action in transgenic mice. Direct and indirect effects of angiotensin II on the heart. J Biol Chem 276, 44012–7 (2001). - PubMed
    1. Mehri S. et al. Angiotensinogen gene polymorphism in acute myocardial infarction patients. J Renin Angiotensin Aldosterone Syst 12, 42–7 (2011). - PubMed
    1. Bleumink G. S. et al. Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study. Eur Heart J 25, 1614–9 (2004). - PubMed

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