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Comparative Study
. 2014 Apr 8;129(14):1493-501.
doi: 10.1161/CIRCULATIONAHA.113.004046. Epub 2014 Feb 26.

The global burden of ischemic heart disease in 1990 and 2010: the Global Burden of Disease 2010 study

Andrew E Moran  1 , Mohammad H Forouzanfar, Gregory A Roth, George A Mensah, Majid Ezzati, Abraham Flaxman, Christopher J L Murray, Mohsen Naghavi
Affiliations
Comparative Study

The global burden of ischemic heart disease in 1990 and 2010: the Global Burden of Disease 2010 study

Andrew E Moran et al. Circulation. .

Abstract

Background: Ischemic heart disease (IHD) burden consists of years of life lost from IHD deaths and years of disability lived with 3 nonfatal IHD sequelae: nonfatal acute myocardial infarction, angina pectoris, and ischemic heart failure. Our aim was to estimate the global and regional burden of IHD in 1990 and 2010.

Methods and results: Global and regional estimates of acute myocardial infarction incidence and angina and heart failure prevalence by age, sex, and world region in 1990 and 2010 were estimated based on data from a systematic review and nonlinear mixed-effects meta-regression methods. Age-standardized acute myocardial infarction incidence and angina prevalence decreased globally between 1990 and 2010; ischemic heart failure prevalence increased slightly. The global burden of IHD increased by 29 million disability-adjusted life-years (29% increase) between 1990 and 2010. About 32.4% of the growth in global IHD disability-adjusted life-years between 1990 and 2010 was attributable to aging of the world population, 22.1% was attributable to population growth, and total disability-adjusted life-years were attenuated by a 25.3% decrease in per capita IHD burden (decreased rate). The number of people living with nonfatal IHD increased more than the number of IHD deaths since 1990, but >90% of IHD disability-adjusted life-years in 2010 were attributable to IHD deaths.

Conclusions: Globally, age-standardized acute myocardial infarction incidence and angina prevalence have decreased, and ischemic heart failure prevalence has increased since 1990. Despite decreased age-standardized fatal and nonfatal IHD in most regions since 1990, population growth and aging led to a higher global burden of IHD in 2010.

Keywords: angina pectoris; epidemiology; heart failure; myocardial infarction; myocardial ischemia; trends; world health.

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Figures

Figure 1
Figure 1
Ischemic heart disease (IHD) disease model, the Global Burden of Disease 2010 Study. AMI indicates acute myocardial infarction; CHF, congestive heart failure; and MI, myocardial infarction.
Figure 2
Figure 2
Years of life lived with disability attributable to ischemic heart disease in 2010, in 21 Global Burden of Disease Study regions. YLD indicates years lived with disability.
Figure 3
Figure 3
Contributions of AMI, angina, and ischemic heart failure to years lived with ischemic heart disease disability in 2010, by sex, in 21 Global Burden of Disease Study regions. AMI indicates acute myocardial infarction.
Figure 4
Figure 4
Disability-adjusted life-years lost owing to ischemic heart disease (IHD DALYs) in 2010, in 21 Global Burden of Disease Study regions.
Figure 5
Figure 5
Contribution of years of life lost (YLL) owing to ischemic heart disease (IHD) deaths and years lived with disability (YLD) because of nonfatal IHD causes (acute myocardial infarction, angina, and heart failure) to the global burden of disease (total disability-adjusted life-years [DALYs], males and females, 2010).
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