Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Aug;59(8):1688-97.
doi: 10.1007/s10620-014-3058-x. Epub 2014 Feb 27.

Molecular therapies in hepatocellular carcinoma: what can we target?

Roberto Galuppo  1 , Dinesh Ramaiah, Oscar Moreno Ponte, Roberto Gedaly
Affiliations
Review

Molecular therapies in hepatocellular carcinoma: what can we target?

Roberto Galuppo et al. Dig Dis Sci. 2014 Aug.

Abstract

Numerous signaling pathways, such as Ras/Raf/MAPK, have been implicated in hepatic carcinogenesis. There are at least 35 combination therapy studies for advanced stage hepatocellular carcinoma (HCC) ongoing, and numerous reagents are being tested targeting novel signaling cascades. The management of HCC has changed substantially in recent times, and the successful development of sorafenib has prompted further expansion on molecular targeted therapies to potentially inhibit different pathways in hepatocarcinogenesis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Updated BCLC staging system and treatment strategy, 2011. [20] (with permission from EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma Journal of Hepatology)
Figure 2
Figure 2
American Liver Tumor Study Group Modified TNM Classification and Staging System[13].
Figure 3
Figure 3
Signaling pathways in HCC
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet. 2003 Dec;362(9399):1907–1917. - PubMed
    1. El-Serag HB. Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma. Gastroenterology. 2012 May;142(6):1264.e1–1273.e1. - PMC - PubMed
    1. El-Serag HB. Hepatocellular carcinoma. N. Engl. J. Med. 2011 Sep;365(12):1118–1127. - PubMed
    1. Sun B, Karin M. Obesity, inflammationm, and liver cancer. J. Hepatol. 2012 Mar;56(3):704–713. - PMC - PubMed
    1. Chen C, Yang H, Yang W, Liu C, Chen P, You S, Wang L, Sun C, Lu S, Chen D, Chen C. Metabolic Factors and Risk of Hepatocellular Carcinoma by Chronic Hepatitis B/C Infection: A Follow-up Study in Taiwan. Gastroenterology. 2008 Jul;135(1):111–121. - PubMed

Publication types

MeSH terms

Substances