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. 2013 Sep;17(3):358-62.
doi: 10.4103/0973-029X.125197.

Immunohistochemical expression of Src protein in peripheral and central giant cell granulomas of the jaws

Monir Moradzadeh Khiavi  1 , Amir Ala Aghbali  2 , Monireh Halimi  3 , Maryam Kouhsoltani  2 , Hamed Hamishehkar  4
Affiliations

Immunohistochemical expression of Src protein in peripheral and central giant cell granulomas of the jaws

Monir Moradzadeh Khiavi et al. J Oral Maxillofac Pathol. 2013 Sep.

Abstract

Aim and objective: The aim of this study was to investigate the expression of Src protein (an osteoclastic factor) in peripheral and central giant cell granulomas (PGCG and CGCGs) of the jaws and the relationship between the expression of this protein and the clinical behavior of these two lesions.

Materials and methods: Thirty cases of PGCG and 30 cases of CGCG were immunohistochemically stained with Src. A staining-intensity-distribution (SID) score (proportion of stained cells × staining intensity) was used to evaluate immunoreactivity of the protein. Data were analyzed using statistical package for social sciences (SPSS) 17.0.

Results: There were no significant differences in the Src expression and the SID score between PGCG and CGCG. Furthermore, Spearman's rank correlation coefficient showed that there was a significant correlation between Src expression and SID score within both PGCG and CGCG (P < 0.001; r = 0.87 and 0.75, respectively).

Conclusion: The findings of this study suggest that the multinucleated giant cells share some similarities with osteoclasts and Src protein can be used as a new therapeutic target to inhibit osteoclastic activity. In addition, differences in immunoreactivity of this osteoclastic protein do not reflect different clinical behaviors of PGCG and CGCG.

Keywords: Central giant cell granuloma; Src; immunohistochemistry; peripheral giant cell granuloma.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
(a) Hematoxylin and Eosin stained section in which the stroma surrounding the multinuclear giant cells is cellular and extravasated red blood cells are seen (H&E stain, ×400), (b) Immunohistochemical staining for peripheral giant cell granuloma showing multinucleated giant cells (MGCs) expressing Src protein (IHC stain, ×400) and (c) Immunohistochemical staining for central giant cell granuloma demonstrating Src positive MGCs (IHC stain, ×400)
Figure 2
Figure 2
The means of Src expression and staining-intensity-distribution (SID) score with error bars in two groups with confidence interval of 95%
Figure 3
Figure 3
Correlation between Src expression and SID score in (a) PGCG (r = 0.87, P < 0.001) and (b) CGCG (r = 0.75, P < 0.001)
See this image and copyright information in PMC

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