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Review
. 2014 Jan 21;20(3):863-8.
doi: 10.3748/wjg.v20.i3.863.

Malignant extra-gastrointestinal stromal tumor of the pancreas: report of two cases and review of the literature

Yan-Tao Tian  1 , Hao Liu  1 , Su-Sheng Shi  1 , Yi-Bin Xie  1 , Quan Xu  1 , Jian-Wei Zhang  1 , Dong-Bing Zhao  1 , Cheng-Feng Wang  1 , Ying-Tai Chen  1
Affiliations
Review

Malignant extra-gastrointestinal stromal tumor of the pancreas: report of two cases and review of the literature

Yan-Tao Tian et al. World J Gastroenterol. .

Abstract

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors that arise from the gastrointestinal tract. In rare cases, these tumors are found in intra-abdominal sites unrelated to the gastrointestinal tract, such as the mesentery, omentum and retroperitoneum. However, pancreatic extra-gastrointestinal stromal tumors are extremely rare, with only 14 previous cases reported. A 61-year-old man with no clinical symptoms had a routine check-up, during which an abdominal mass located in the pancreas tail was detected. Abdominal surgery was performed with resection of the pancreas tail and the spleen, and he was diagnosed with low-risk GISTs. Another 60-year-old man with no clinical symptoms underwent Computed tomography which revealed a well-demarcated tumor, 6 cm in diameter, in the head of the pancreas. He was diagnosed with pancreatic GISTs. Here, we describe two rare cases of pancreatic GISTs and review the cases previously reported in the literature.

Keywords: Extra-gastrointestinal Stromal Tumors; Gastrointestinal Stromal tumors; Pancreatic gastrointestinal stromal tumors.

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Figures

Figure 1
Figure 1
An abdominal mass was detected by ultrasound in a 61-year-old man with no clinical symptoms. A: Enhanced abdominal computed tomography scan showed a solid mass of the pancreatic body, and the tumor located at pancreas tail next to splenic artery; B: The tumor was composed of spindle cell (HE, × 200); C: Immunoreactivity of the tumor cells for CD117 was positive (+) (SP × 100); D: Immunoreactivity of the tumor cells for CD34 was positive (++) (SP × 200).
Figure 2
Figure 2
A 60-year-old man with no clinical symptoms underwent computed tomography. A: Enhanced abdominal computed tomography scan showed a solid mass in the pancreatic head; B: The tumor was composed of spindle cell (HE, × 200); C: Immunoreactivity of the tumor cells for CD117 was positive (+) (SP × 200); D: Immunoreactivity of the tumor cells for DOG-1 was positive (+++) (SP × 200).
See this image and copyright information in PMC

References

    1. Joensuu H, Roberts PJ, Sarlomo-Rikala M, Andersson LC, Tervahartiala P, Tuveson D, Silberman S, Capdeville R, Dimitrijevic S, Druker B, et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med. 2001;344:1052–1056. - PubMed
    1. Reith JD, Goldblum JR, Lyles RH, Weiss SW. Extragastrointestinal (soft tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome. Mod Pathol. 2000;13:577–585. - PubMed
    1. Miettinen M, Lasota J. Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol. 2006;23:70–83. - PubMed
    1. Miettinen M, Monihan JM, Sarlomo-Rikala M, Kovatich AJ, Carr NJ, Emory TS, Sobin LH. Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases. Am J Surg Pathol. 1999;23:1109–1118. - PubMed
    1. Vij M, Agrawal V, Pandey R. Malignant extra-gastrointestinal stromal tumor of the pancreas. A case report and review of literature. JOP. 2011;12:200–204. - PubMed