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Review
. 2014 Jan 28;20(4):1107-13.
doi: 10.3748/wjg.v20.i4.1107.

Meta-analysis of immunohistochemical expression of hypoxia inducible factor-1α as a prognostic role in gastric cancer

Shuang Lin  1 , Rui Ma  1 , Xue-Yong Zheng  1 , Hong Yu  1 , Xiao Liang  1 , Hui Lin  1 , Xiu-Jun Cai  1
Affiliations
Review

Meta-analysis of immunohistochemical expression of hypoxia inducible factor-1α as a prognostic role in gastric cancer

Shuang Lin et al. World J Gastroenterol. .

Abstract

Aim: To conduct a meta-analysis to evaluate the prognostic role of hypoxia inducible factor-1α (HIF-1α) expression in gastric cancer.

Methods: The PubMed, EMBASE, and Web of Science databases were searched systematically for all articles published in English before August, 2013. Pooled effect was calculated from the available data to evaluate the association between HIF-1α expression and 5-year overall survival and tumor clinicopathological features in gastric cancer patients. Pooled odds ratios (ORs) with 95%CIs were calculated using either a fixed-effects or a random-effects model.

Results: Nine studies matched the selection criteria, which reported on 1103 subjects, 548 of whom had HIF-1α positive expression (50%). This meta-analysis indicated that HIF-1α positive expression in gastric cancer correlated with lower 5-year overall survival (OR = 0.36; 95%CI: 0.21-0.64), worse tumor differentiation (OR = 0.38; 95%CI: 0.23-0.64), deeper invasion (OR = 0.42; 95%CI: 0.32-0.57), higher rates of lymph node metastasis (OR = 2.23; 95%CI: 1.46-3.40), lymphatic invasion (OR = 2.50; 95%CI: 1.46-4.28), and vascular invasion (OR = 1.80; 95%CI: 1.29-2.51), and higher TNM stage (III + IV) (OR = 0.31; 95%CI: 0.15-0.60).

Conclusion: HIF-1α positive expression indicates a poor prognosis for patients with gastric cancer. Further studies are required to confirm these results.

Keywords: 5-year overall survival; Clinicopathological features; Gastric cancer; Hypoxia inducible factor-1α; Meta-analysis.

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Figures

Figure 1
Figure 1
Flow diagram indicating the process of selecting articles for meta-analysis.
Figure 2
Figure 2
Forest plots. A: The results of the meta-analysis for 5-year overall survival; B: The results of the meta-analysis for tumor differentiation; C: The results of the meta-analysis for depth of invasion; D: The results of the meta-analysis for lymph node metastasis (LNM); E: The results of the meta-analysis for vascular invasion; F: The results of the meta-analysis for lymphatic invasion; G: The results of the meta-analysis for tumor node metastasis stage.
Figure 3
Figure 3
Funnel plot of studies of hypoxia inducible factor-1α positive expression in gastric cancer.
See this image and copyright information in PMC

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