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Review
. 2014 Feb 12:5:48.
doi: 10.3389/fphys.2014.00048. eCollection 2014.

Advancements in stem cells treatment of skeletal muscle wasting

Mirella Meregalli  1 , Andrea Farini  1 , Clementina Sitzia  1 , Yvan Torrente  1
Affiliations
Review

Advancements in stem cells treatment of skeletal muscle wasting

Mirella Meregalli et al. Front Physiol. .

Abstract

Muscular dystrophies (MDs) are a heterogeneous group of inherited disorders, in which progressive muscle wasting and weakness is often associated with exhaustion of muscle regeneration potential. Although physiological properties of skeletal muscle tissue are now well known, no treatments are effective for these diseases. Muscle regeneration was attempted by means transplantation of myogenic cells (from myoblast to embryonic stem cells) and also by interfering with the malignant processes that originate in pathological tissues, such as uncontrolled fibrosis and inflammation. Taking into account the advances in the isolation of new subpopulation of stem cells and in the creation of artificial stem cell niches, we discuss how these emerging technologies offer great promises for therapeutic approaches to muscle diseases and muscle wasting associated with aging.

Keywords: fibrosis; inflammation; muscle wasting; myogenic stem cell; stem cell niche.

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References

    1. Abbott A. (2003). Cell culture: biology's new dimension. Nature 424, 870–872 10.1038/424870a - DOI - PubMed
    1. Adams G. B., Martin R. P., Alley I. R., Chabner K. T., Cohen K. S., Calvi L. M., et al. (2007). Therapeutic targeting of a stem cell niche. Nat. Biotechnol. 25, 238–243 10.1038/nbt1281 - DOI - PubMed
    1. Alessandri G., Pagano S., Bez A., Benetti A., Pozzi S., Iannolo G., et al. (2004). Isolation and culture of human muscle-derived stem cells able to differentiate into myogenic and neurogenic cell lineages. Lancet 364, 1872–1883 10.1016/S0140-6736(04)17443-6 - DOI - PubMed
    1. Alhadlaq A., Mao J. J. (2004). Mesenchymal stem cells: isolation and therapeutics. Stem Cells Dev. 13, 436–448 10.1089/scd.2004.13.436 - DOI - PubMed
    1. Amit M., Itskovitz-Eldor J. (2002). Derivation and spontaneous differentiation of human embryonic stem cells. J. Anat. 200, 225–232 10.1046/j.1469-7580.2002.00032.x - DOI - PMC - PubMed