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Review
. 2014 Feb 11:5:46.
doi: 10.3389/fimmu.2014.00046. eCollection 2014.

Regulatory T cells as immunotherapy

Benjamin D Singer  1 , Landon S King  1 , Franco R D'Alessio  1
Affiliations
Review

Regulatory T cells as immunotherapy

Benjamin D Singer et al. Front Immunol. .

Abstract

Regulatory T cells (Tregs) suppress exuberant immune system activation and promote immunologic tolerance. Because Tregs modulate both innate and adaptive immunity, the biomedical community has developed an intense interest in using Tregs for immunotherapy. Conditions that require clinical tolerance to improve outcomes - autoimmune disease, solid organ transplantation, and hematopoietic stem cell transplantation - may benefit from Treg immunotherapy. Investigators have designed ex vivo strategies to isolate, preserve, expand, and infuse Tregs. Protocols to manipulate Treg populations in vivo have also been considered. Barriers to clinically feasible Treg immunotherapy include Treg stability, off-cell effects, and demonstration of cell preparation purity and potency. Clinical trials involving Treg adoptive transfer to treat graft versus host disease preliminarily demonstrated the safety and efficacy of Treg immunotherapy in humans. Future work will need to confirm the safety of Treg immunotherapy and establish the efficacy of specific Treg subsets for the treatment of immune-mediated disease.

Keywords: adoptive transfer; expansion; immunotherapeutics; inflammation; regulatory T cells; tolerance.

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Figures

Figure 1
Figure 1
Schematic of a strategy to isolate, expand, and infuse Tregs.
See this image and copyright information in PMC

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References

    1. Christen U, von Herrath MG. Initiation of autoimmunity. Curr Opin Immunol (2004) 16:759–6710.1016/j.coi.2004.09.002 - DOI - PubMed
    1. Rosenberg AS, Singer A. Cellular basis of skin allograft rejection: an in vivo model of immune-mediated tissue destruction. Annu Rev Immunol (1992) 10:333–5810.1146/annurev.iy.10.040192.002001 - DOI - PubMed
    1. Trenado A, Charlotte F, Fisson S, Yagello M, Klatzmann D, Salomon BL, et al. Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. J Clin Invest (2003) 112:1688–9610.1172/JCI17702 - DOI - PMC - PubMed
    1. Edinger M, Hoffmann P, Ermann J, Drago K, Fathman CG, Strober S, et al. CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med (2003) 9:1144–5010.1038/nm915 - DOI - PubMed
    1. Sakaguchi S, Sakaguchi N, Shimizu J, Yamazaki S, Sakihama T, Itoh M, et al. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev (2001) 182:18–3210.1034/j.1600-065X.2001.1820102.x - DOI - PubMed