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. 2014:2014:256813.
doi: 10.1155/2014/256813. Epub 2014 Jan 20.

Primary intraparenchymal squamous cell carcinoma of the kidney: a rare and unique entity

Prithwijit Ghosh  1 , Kaushik Saha  2
Affiliations

Primary intraparenchymal squamous cell carcinoma of the kidney: a rare and unique entity

Prithwijit Ghosh et al. Case Rep Pathol. 2014.

Abstract

Primary squamous cell carcinoma (SCC) of the renal parenchyma is a very unusual entity which needs to be differentiated from primary SCC of renal pelvis, SCC from another primary site, and urothelial carcinoma with extensive squamous differentiation. We are most probably describing the second case of primary SCC of the renal parenchyma in a 51-year-old male who presented with heaviness of right upper abdomen with intermittent pain in right flank. Contrast-enhanced computed tomography (CECT) revealed a mass in the right lower pole of the kidney and histopathology following nephrectomy displayed the features of well-differentiated squamous cell carcinoma without urothelial involvement.

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Figures

Figure 1
Figure 1
(a) CECT of abdomen on coronal plane showing a solitary mass in the lower pole of right kidney. (b) Photograph of bisected specimen of nephrectomy showing a well-delineated mass in the lower pole.
Figure 2
Figure 2
(a) Photomicrograph of well-differentiated squamous cell carcinoma with keratin pearl formation along with glomeruli and tubules (H and E, ×100). (b) Glomerulus and tubules in close relation to keratin pearl of squamous cell carcinoma (H and E, ×400). (c) Photomicrograph of entrapped glomerulus and renal tubules within squamous cell carcinoma (H and E, ×400). (d) Photomicrograph of uninvolved flattened urothelium of pelvicalyceal system (left) keeping a distance from sheets of malignant squamous cells (right) (H and E, ×100).
See this image and copyright information in PMC

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