The autoreactive T cell population in experimental allergic encephalomyelitis: T cell receptor beta-chain rearrangements
- PMID: 2457602
- DOI: 10.1016/0165-5728(88)90002-1
The autoreactive T cell population in experimental allergic encephalomyelitis: T cell receptor beta-chain rearrangements
Abstract
T cell receptor beta-chain gene rearrangements were examined in myelin basic protein (MBP)-reactive T cell lines and hybridomas from Lewis (Lew) rats. Nearly 75% of the cloned hybrids were specific for the major encephalitogenic determinant residues 68-88 of guinea pig (GP) MBP; three fine specificities could be distinguished. Southern blot analysis of receptor beta-chain genes revealed polyclonality and shared rearrangements not seen in non-68-88-specific clones. Generation of short-term, encephalitogenic Lew T cell lines revealed rearrangements shared with the 68-88-specific hybrids, indicating that the hybrids were representative of the whole antigen-specific population and suggesting restricted V beta gene usage within this polyclonal population.
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