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Comment
. 2014 Mar;16(3):210-2.
doi: 10.1038/ncb2925.

SIK2 regulates insulin secretion

Bengt-Frederik Belgardt  1 , Markus Stoffel  1
Affiliations
Comment

SIK2 regulates insulin secretion

Bengt-Frederik Belgardt et al. Nat Cell Biol. 2014 Mar.

Abstract

Correct regulation of insulin secretion by the pancreas is crucial for organismal function and survival. The AMPK-related kinase SIK2 (salt-inducible kinase 2) is now shown to be stabilized in pancreatic β-cells following glucose stimulation, leading to improved systemic glucose homeostasis by regulating cellular calcium flux and insulin secretion.

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