Adrenoceptor-mediated changes of excitation and contraction in ventricular heart muscle from guinea-pigs and rabbits
- PMID: 2457704
- PMCID: PMC1192148
- DOI: 10.1113/jphysiol.1988.sp017024
Adrenoceptor-mediated changes of excitation and contraction in ventricular heart muscle from guinea-pigs and rabbits
Abstract
1. The influence of alpha-adrenoceptor stimulation on mechanical and electrophysiological parameters was investigated in ventricular preparations from guinea-pigs and rabbits. Action potential and force of contraction were measured in papillary muscles and ionic currents were measured in isolated myocytes. 2. The effects of alpha-adrenoceptor stimulation were compared with those of beta-adrenoceptor stimulation. 3. In the guinea-pig the stimulation of alpha-adrenoceptors caused a small increase in the force of contraction (less than 10% of the response to beta-adrenoceptor stimulation) which was not accompanied by any increase of the slow calcium inward current. beta-Adrenoceptor stimulation produced large increases in both force of contraction and slow inward calcium current. The noradrenaline-induced increase in the slow inward calcium current was not affected by phentolamine. 4. In the rabbit, alpha-adrenoceptor stimulation produced large increases in the force of contraction (about two thirds of those seen in response to beta-adrenoceptor stimulation). Whereas beta-adrenoceptor stimulation also produced large increases in both maximal upstroke velocity of slow-response action potentials and slow inward calcium current, there was almost no change of both parameters in response to alpha-adrenoceptor stimulation. 5. We conclude that, first, the contribution of alpha-adrenoceptors to adrenoceptor-mediated changes of force of contraction is minimal in the guinea-pig ventricle, and second, the pronounced changes of force of contraction in the rabbit ventricle in response to alpha-adrenoceptor stimulation are unrelated to changes in the slow inward calcium current.
Similar articles
-
Effects of alpha-adrenoceptor stimulation with phenylephrine in the presence of propranolol on force of contraction, slow inward current and cyclic AMP content in the bovine heart.Br J Pharmacol. 1984 May;82(1):223-32. doi: 10.1111/j.1476-5381.1984.tb16462.x. Br J Pharmacol. 1984. PMID: 6329389 Free PMC article.
-
[Effect of myocardial alpha 1-adrenoceptor stimulation on the guinea-pig ventricular papillary muscle].Sheng Li Xue Bao. 1989 Oct;41(5):459-69. Sheng Li Xue Bao. 1989. PMID: 2557676 Chinese.
-
Adrenoceptor-mediated changes of action potential and force of contraction in human isolated ventricular heart muscle.Br J Pharmacol. 1988 Jun;94(2):584-90. doi: 10.1111/j.1476-5381.1988.tb11564.x. Br J Pharmacol. 1988. PMID: 2840164 Free PMC article.
-
Adrenoceptor-mediated changes of excitation and contraction in isolated heart muscle preparations.J Cardiovasc Pharmacol. 1989;14 Suppl 3:S1-10. doi: 10.1097/00005344-198914003-00002. J Cardiovasc Pharmacol. 1989. PMID: 2478796 Review.
-
[Alpha-adrenoceptors in the myocardium: incidence and functional significance].Klin Wochenschr. 1985 Nov 4;63(21):1087-97. doi: 10.1007/BF02291089. Klin Wochenschr. 1985. PMID: 3001400 Review. German.
Cited by
-
Adrenergic control of the ultrarapid delayed rectifier current in canine atrial myocytes.J Physiol. 1999 Apr 15;516 ( Pt 2)(Pt 2):385-98. doi: 10.1111/j.1469-7793.1999.0385v.x. J Physiol. 1999. PMID: 10087339 Free PMC article.
-
Modulation of L-type calcium channels by sodium ions.Proc Natl Acad Sci U S A. 1992 May 15;89(10):4417-21. doi: 10.1073/pnas.89.10.4417. Proc Natl Acad Sci U S A. 1992. PMID: 1374902 Free PMC article.
-
Mechanisms Underlying Spontaneous Action Potential Generation Induced by Catecholamine in Pulmonary Vein Cardiomyocytes: A Simulation Study.Int J Mol Sci. 2019 Jun 14;20(12):2913. doi: 10.3390/ijms20122913. Int J Mol Sci. 2019. PMID: 31207916 Free PMC article.
-
Anion and cation modulation of the guinea-pig ventricular action potential during beta-adrenoceptor stimulation.Pflugers Arch. 1993 Jun;424(1):54-62. doi: 10.1007/BF00375102. Pflugers Arch. 1993. PMID: 8394573
-
Alpha 1-adrenergic effects on intracellular pH and calcium and on myofilaments in single rat cardiac cells.J Physiol. 1992 Feb;447:275-92. doi: 10.1113/jphysiol.1992.sp019002. J Physiol. 1992. PMID: 1317431 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources