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. 2014 Feb 26;19(3):2733-47.
doi: 10.3390/molecules19032733.

Chemical composition, biological and cytotoxic activities of plant extracts and compounds isolated from Ferula lutea

Mansour Znati  1 , Ben Jannet Hichem  2 , Sylvie Cazaux  1 , Jalloul Bouajila  3
Affiliations

Chemical composition, biological and cytotoxic activities of plant extracts and compounds isolated from Ferula lutea

Mansour Znati et al. Molecules. .

Abstract

The present work describes the phytochemical study on Ferula lutea flowers. Total phenolics and flavonoids of the n-butanol and ethyl acetate extracts were quantified (phenolics [40.68-52.29 mg gallic acid equivalent/g of dry weight], flavonoids [12.38-14.72 mg quercitin/g dry weight]). Two diastereoisomers were isolated and identified using spectroscopic techniques (1D, 2D NMR and GC-MS). The extracts and diastereoisomers were tested for antioxidant, antiacetylcholinesterase, antimicrobial, antidiabectic, cytotoxic (leukemia cell line) activities and allelopathic potentialities. The strongest antioxidant activity was obtained for the ethyl acetate extract (IC₅₀ = 12.8 ± 1.29 µg/mL). The two extracts exhibited high antidiabetic activity (54.1 and 52.1% at 40 µg/mL).

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structure of (+)-Z-deltoin (1a, major compound) and (−)-E-deltoin (1b, minor compound).
Figure 2
Figure 2
Duplication of signals in 1H-NMR of the mixture of compounds 1a and 1b.
Figure 3
Figure 3
Roots (R) and shoots length (PA), expressed in percent of control, of lettuce in presence (1 mg/mL) of (EAE), n-butanol extract (BE) and two diastereoisomers (1a and 1b) (C1) of F. lutea; 7 days after germination.
Figure 4
Figure 4
Germination of lettuce seeds in the presence (1 mg/mL) of distilled water (control), ethyl acetate (EAE), n-butanolic extract (BE) and two diastereoisomers (1a and 1b) (C1) of F. lutea.
See this image and copyright information in PMC

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