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. 2014 Feb;55(1):38-44.
doi: 10.3325/cmj.2014.55.38.

Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men

Karlo Golubić  1 , Anton Šmalcelj, Jadranka Sertić, Ljiljana Juričić
Affiliations

Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men

Karlo Golubić et al. Croat Med J. 2014 Feb.

Abstract

Aim: To determine the association between the number of thymine-adenine (TA)n dinucleotide repeats in the promoter region of the gene coding for the estrogen receptor alpha (ESR1) and the prevalence of lone atrial fibrillation (AF) in men.

Methods: We conducted a case-control study involving 89 men with lone AF and 166 healthy male controls. The ESR1 genotype was established by polymerase chain reaction and capillary electrophoresis. To assess the association of ESR1 genotype with AF, logistic regression models were built with AF as outcome.

Results: Men with lone AF had significantly greater number of (TA)n repeats of single alleles than controls (mean ± standard deviation, 19.2 ± 4.2 vs 18 ± 4.3, P = 0.010). After adjustment for other factors, a unit-increase in (TA)n repeat number was associated with a significantly greater likelihood of AF (odds ratio 1.069; 95% confidence interval 1.024-1.116, P=0.002).

Conclusions: Our results indicate that a greater number of (TA)n repeats in the promoter region of ESR1 is associated with a significantly increased likelihood of lone atrial fibrillation in men.

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Figures

Figure 1
Figure 1
The stepwise exclusion process of cases and controls.
Figure 2
Figure 2
Bimodal distribution of (TA)n repeats in cases and controls.
Figure 3
Figure 3
The association between the prevalence of lone atrial fibrillation and sums of (TA)n repeats of both alleles.
See this image and copyright information in PMC

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