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. 2014 Jul;28(4):306-9.
doi: 10.1002/jcla.21685. Epub 2014 Feb 27.

A study of hepcidin and monocyte chemoattractant protein-1 in Egyptian females with systemic lupus erythematosus

Moataz Fatthy Mohammed  1 , Dawlat Belal, Seham Bakry, Mohamed A Marie, Laila Rashed, Reham Emad Eldin, Samah Abd El-Hamid
Affiliations

A study of hepcidin and monocyte chemoattractant protein-1 in Egyptian females with systemic lupus erythematosus

Moataz Fatthy Mohammed et al. J Clin Lab Anal. 2014 Jul.

Abstract

Background: Lupus nephritis is one of the most serious manifestations of systemic lupus erythematosus (SLE). Novel biomarkers are necessary to enhance the diagnostic accuracy, prognostic stratification, monitoring of treatment response, and detection of early renal flares.

Methods: Our study was conducted on 90 participants. They were divided into three groups, group I (controls) encompassed 30 ages and sex-matched healthy personnel. Group II included 30 non-nephritic SLE patients and finally group III included 30 SLE nephritic patients. Urinary monocyte chemoattractant protein-1 (UMCP-1) and hepcidin were evaluated by ELISA technique, compared and correlated in different groups, with each other and with other routine variables and with renal biopsy done to study group (III).

Results: Both UMCP-1 and hepcidin in group III showed significant increase compared to other two groups (controls and group II) (468 ± 128, 111 ± 12, 252 ± 56 pg/ml, respectively, for UMCP-1 and 40 ± 12, 11 ± 2, 20 ± 5 ng/ml, respectively, for hepcidin, P < 0.01). Also both UMCP-1 and hepcidin in group III showed significant increase in diffuse proliferative subgroup compared to focal proliferative and mesangioproliferative subgroups (580 ± 43, 502 ± 46, and 352.6 ± 100 pg/ml, respectively, for UMCP-1 and 47.8 ± 9.5, 41.4 ± 6, and 32.9 ± 10.8 ng/ml, respectively, for urinary hepcidin, P < 0.05).

Conclusion: UMCP-1 and hepcidin could be associated with the susceptibility of lupus nephritis.

Keywords: hepcidin; lupus nephritis; monocyte chemoattractant protein-1; urinary biomarkers.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Correlation between UMCP‐1 and urinary hepcidin in group III (r = 0.516, P = 0.003).
See this image and copyright information in PMC

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