Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Feb 25:6.
doi: 10.3402/jom.v6.22962. eCollection 2014.

Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases

Luigi Nibali  1 , Brian Henderson  2 , Syed Tariq Sadiq  3 , Nikos Donos  1
Affiliations
Review

Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases

Luigi Nibali et al. J Oral Microbiol. .

Abstract

Thousands of bacterial phylotypes colonise the human body and the host response to this bacterial challenge greatly influences our state of health or disease. The concept of infectogenomics highlights the importance of host genetic factors in determining the composition of human microbial biofilms and the response to this microbial challenge. We hereby introduce the term 'genetic dysbiosis' to highlight the role of human genetic variants affecting microbial recognition and host response in creating an environment conducive to changes in the normal microbiota. Such changes can, in turn, predispose to, and influence, diseases such as: cancer, inflammatory bowel disease, rheumatoid arthritis, psoriasis, bacterial vaginosis and periodontitis. This review presents the state of the evidence on host genetic factors affecting dysbiosis and microbial misrecognition (i.e. an aberrant response to the normal microbiota) and highlights the need for further research in this area.

Keywords: dysbiosis; genetic; inflammation; microbiome.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Schematic representation of potential pathogenic pathways of genetic dysbioses.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. McFall-Ngai M, Henderson B, Ruby N, editors. New York: Cambridge University Press; 2005. The influence of cooperative bacteria on animal host biology.
    1. Ruby E, Henderson B, McFall-Ngai M. Microbiology – we get by with a little help from our (little) friends. Science. 2004;303:1305–7. - PubMed
    1. Wilson M. New York: Cambridge University Press; 2005. Bacterial inhabitants of humans: their ecology and role in health and disease.
    1. Wu GD, Lewis JD. Analysis of the human gut microbiome and association with disease. Clin Gastroenterol Hepatol. 2013;7:774–7. - PMC - PubMed
    1. Wilson M. Bacteriology of humans: an ecological perspective. Oxford: Blackwell; 2008.