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Randomized Controlled Trial
. 2014 Feb;14(1):40-4.
doi: 10.17305/bjbms.2014.2295.

Influence of Rho kinase inhibitor Fasudil on late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension

Pei Liu  1 , Hongmei Zhang  2 , Yijun Tang  2 , Chunfeng Sheng  1 , Jianxin Liu  3 , Yanjun Zeng  4
Affiliations
Randomized Controlled Trial

Influence of Rho kinase inhibitor Fasudil on late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension

Pei Liu et al. Bosn J Basic Med Sci. 2014 Feb.

Abstract

The objective of our work was to investigate the influence of Fasudil, a Rho inhibitor on the number and function of the late endothelial progenitor cells in peripheral blood of chronic obstructive pulmonary diseases (COPD) patients with pulmonary artery hypertension. Eighty COPD patients with pulmonary artery hypertension were selected and divided into two groups: the treatment group and the control group, which had 40 patients respectively. The control group received routine treatment, including oxygen uptake, anti-infection and phlegm dissolving. The treatment group received the Fasudil in addition to the routine treatment. The changes on the number and function of the late endothelial progenitor cells in peripheral blood of the patients before and after the treatment were compared between the two groups. The changes on the pulmonary artery pressure were also compared. The number of the late endothelial progenitor cells in peripheral blood of the treatment group increased and the function was enhanced. The pulmonary artery pressure was reduced. The difference before and after the treatment and with the control group was statistically significant (p<0.05). The changes on the number and function of the late endothelial progenitor cells in peripheral blood and the pulmonary artery pressure before and after the treatment of the control group were not statistically significant (p>0.05). The Rho-kinase inhibitor Fasudil increased the number and enhanced the function of the late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension.

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Figures

FIGURE 1
FIGURE 1
The late EPC cultured in isolation was measured for the positivity of cell phenotypes of CD34 and KDR by a flow cytometry.
FIGURE 2
FIGURE 2
The absorption of DiLDL combining with FITC-UEA-I (double positivity)
See this image and copyright information in PMC

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