Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Mar 19;136(11):4141-4.
doi: 10.1021/ja501014b. Epub 2014 Mar 5.

Iridium-catalyzed intermolecular amidation of sp³ C-H bonds: late-stage functionalization of an unactivated methyl group

Affiliations

Iridium-catalyzed intermolecular amidation of sp³ C-H bonds: late-stage functionalization of an unactivated methyl group

Taek Kang et al. J Am Chem Soc. .

Abstract

Reported herein is the iridium-catalyzed direct amidation of unactivated sp(3) C-H bonds. With sulfonyl and acyl azides as the amino source, the amidation occurs efficiently under mild conditions over a wide range of unactivated methyl groups with high functional group tolerance. This procedure can be successfully applied for the direct introduction of an amino group into complex compounds and thus can serve as a powerful synthetic tool for late-stage C-H functionalization.

PubMed Disclaimer

Publication types

LinkOut - more resources