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. 2014 Mar;30(3):133-8.
doi: 10.1016/j.kjms.2013.10.003. Epub 2013 Dec 3.

Association between auditory P300, psychopathology, and memory function in drug-naïve schizophrenia

Wei-Hung Chang  1 , Kao-Chin Chen  1 , Yen-Kuang Yang  2 , Po-See Chen  2 , Ru-Band Lu  3 , Tzung-Lieh Yeh  2 , Carol Sheei-Meei Wang  4 , I-Hui Lee  5
Affiliations

Association between auditory P300, psychopathology, and memory function in drug-naïve schizophrenia

Wei-Hung Chang et al. Kaohsiung J Med Sci. 2014 Mar.

Abstract

The aim of this study was to explore memory deficits and psychopathology and their relationships with P300 in drug-naïve patients with schizophrenia. The Positive and Negative Syndrome Scale (PANSS) and the Wechsler Memory Scale-Revised were administered. Auditory event-related potentials elicited by an oddball paradigm were obtained. After controlling for age, sex, the results showed a statistically significant negative correlation between the total PANSS score and P300 amplitude at the parietal position (r = -0.66, p < 0.05). Moreover, visual memory was significantly positively correlated with P300 amplitude at the parietal position (r = 0.67, p < 0.05). After controlling for the duration of illness, the above correlations remained statistically significant. The correlation between P300 and the severity of psychopathology was reconfirmed in drug-naïve patients with schizophrenia. A possible contribution of memory decompensation in P300 among drug-naïve patients with schizophrenia may be considered, and the compensatory or Default Model Network might be a possible explanation of this association.

Keywords: Default model network; Drug-naïve schizophrenia; P300; Psychopathology; Visual memory.

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