Structural organisation of the type IV secretion systems
- PMID: 24581689
- PMCID: PMC3969286
- DOI: 10.1016/j.mib.2013.11.001
Structural organisation of the type IV secretion systems
Abstract
Type IV secretion (T4S) systems are large dynamic nanomachines that transport DNAs and/or proteins through the membranes of bacteria. Because of their complexity and multi-protein organisation, T4S systems have been extremely challenging to study structurally. However in the past five years significant milestones have been achieved by X-ray crystallography and cryo-electron microscopy. This review describes some of the more recent advances: the structures of some of the protein components of the T4S systems and the complete core complex structure that was determined using electron microscopy.
Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.
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