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. 2014 Mar:157:41-4.
doi: 10.1016/j.jad.2013.12.042. Epub 2014 Jan 11.

A preliminary report of increased plasma levels of IL-33 in bipolar disorder: further evidence of pro-inflammatory status

Izabela Guimaraes Barbosa  1 , Isabela Boechat Morato  2 , Aline Silva de Miranda  2 , Moisés Evandro Bauer  3 , Jair C Soares  4 , Antônio Lucio Teixeira  5
Affiliations

A preliminary report of increased plasma levels of IL-33 in bipolar disorder: further evidence of pro-inflammatory status

Izabela Guimaraes Barbosa et al. J Affect Disord. 2014 Mar.

Abstract

Background: Recent findings suggest an important role for inflammation in the neurobiology of bipolar disorder (BD). Interleukin 33 (IL-33) is a cytokine with multiple functions and may act as a nuclear factor regulating transcription and as an "alarmin". IL-33 exerts part of its function through the receptor ST2 that also exists in a soluble form (sST2). This study was performed to evaluate IL-33 and sST2 plasma levels in BD patients.

Methods: We evaluated IL33 and sST2 plasma levels of 46 BD patients (23 in euthymia and 23 in mania) and 23 healthy controls using enzyme-linked immunosorbent assay (ELISA). BD patients were age and gender matched healthy controls.

Results: IL-33 levels were higher in BD patients (p=0.02) but there was no difference in sST2 (p=0.55). IL33 and sST2 plasma levels were not correlated with age, neither was influenced by clinical comorbidities nor medications in use.

Conclusion: These findings corroborate the view of BD as a multisystem condition with a proinflammatory profile.

Keywords: Bipolar disorder; Depression; IL-33; Mania; sST2.

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