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. 1988 Jun 22;151(1):131-4.
doi: 10.1016/0014-2999(88)90702-9.

Neuropeptide Y blocks a calcium current in C cells of bullfrog sympathetic ganglia

G G Schofield  1 , S R Ikeda
Affiliations

Neuropeptide Y blocks a calcium current in C cells of bullfrog sympathetic ganglia

G G Schofield et al. Eur J Pharmacol. .

Abstract

The effects of neuropeptide Y (NPY) on the Ca2+ current of enzymatically dispersed neuronal somata from bullfrog paravertebral sympathetic ganglia were investigated using the patch-clamp technique. In C neurons, NPY induced a concentration-dependent decrease in the amplitude of the Ca2+ current and induced a slow biphasic current rising phase. Upon removal of NPY these parameters returned to near control values. NPY had no discernable effect on the Ca2+ current recorded in B neurons.

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