SV40 TAg mouse models of cancer

Emily K Colvin¹, Chris Weir², Rowan J Ikin³, Amanda L Hudson⁴

Affiliations

¹ Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia. Electronic address: emily.colvin@sydney.edu.au.
² Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia. Electronic address: chris.weir@sydney.edu.au.
³ Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia. Electronic address: rowan.ikin@sydney.edu.au.
⁴ Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia. Electronic address: Amanda.Hudson@sydney.edu.au.

PMID: 24583142
DOI: 10.1016/j.semcdb.2014.02.004

Review

SV40 TAg mouse models of cancer

Emily K Colvin et al. Semin Cell Dev Biol. 2014 Mar.

. 2014 Mar:27:61-73.

doi: 10.1016/j.semcdb.2014.02.004. Epub 2014 Feb 25.

Authors

Emily K Colvin¹, Chris Weir², Rowan J Ikin³, Amanda L Hudson⁴

Affiliations

¹ Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia. Electronic address: emily.colvin@sydney.edu.au.
² Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia. Electronic address: chris.weir@sydney.edu.au.
³ Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia. Electronic address: rowan.ikin@sydney.edu.au.
⁴ Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia. Electronic address: Amanda.Hudson@sydney.edu.au.

PMID: 24583142
DOI: 10.1016/j.semcdb.2014.02.004

Abstract

The discovery of a number of viruses with the ability to induce tumours in animals and transform human cells has vastly impacted cancer research. Much of what is known about tumorigenesis today regarding tumour drivers and tumour suppressors has been discovered through experiments using viruses. The SV40 virus has proven extremely successful in generating transgenic models of many human cancer types and this review provides an overview of these models and seeks to give evidence as to their relevance in this modern era of personalised medicine and technological advancements.

Keywords: Cancer; Mouse model; SV40; Transgenic.

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SV40 TAg mouse models of cancer

Affiliations

SV40 TAg mouse models of cancer

Authors

Affiliations

Abstract

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LinkOut - more resources

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