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Review
. 2014 Mar;29(2):141-9.
doi: 10.1152/physiol.00040.2013.

Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides

Oliver Lomas  1 , Manuela Zaccolo
Affiliations
Review

Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides

Oliver Lomas et al. Physiology (Bethesda). 2014 Mar.

Abstract

Novel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and disease. The concept of compartmentalization is guiding the search for therapies that have the potential to offer greater efficacy and tolerability compared with current treatments.

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Conflict of interest statement

No conflicts of interest, financial or otherwise, are declared by the author(s).

Figures

FIGURE 1.
FIGURE 1.
Cartoon depicting compartmentalization and cGMP- and cAMP-dependent signaling cross talk in a cardiomyocyte β-AR, β-adrenoceptor; LTCC, L-type calcium current; TnI, Troponin I; PLB, phospholamban; AC, adenylyl cyclase; sGC, soluble guanylyl cyclase; PGR, prostaglandin receptor. Arrows indicate stimulation. Blunt lines indicate inhibition.
FIGURE 2.
FIGURE 2.
Cartoon depicting how interrupted subcellular PKA-cAMP microdomain signaling may affect cardiac hypertrophic growth Hsp20, heat shock protein 20. Red bar indicates disruptive peptide.
See this image and copyright information in PMC

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