Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2014;13(7):1053-4.
doi: 10.4161/cc.28377. Epub 2014 Feb 28.

mTORC2 dictates Warburg effect and drug resistance

Kenta Masui  1 , Webster K Cavenee  2 , Paul S Mischel  3
Affiliations
Editorial

mTORC2 dictates Warburg effect and drug resistance

Kenta Masui et al. Cell Cycle. 2014.
No abstract available

Keywords: FoxO; acetylation; c-Myc; drug resistance; glioblastoma; mTORC2; metabolic reprogramming.

PubMed Disclaimer

Figures

None
Figure 1. mTORC2 is a kingpin of the Warburg effect and drug resistance. mTORC2 inhibits FoxO via acetylation, whereas PI3K/Akt via phosphorylation, leading to the upregulation of c-Myc, a key effector of the Warburg effect. PI3K/Akt-targeted therapies alone can be bypassed by mTORC2-mediated pathways, whereas targeting both PI3K/Akt and mTORC2 potently suppresses c-Myc and the Warburg effect.
See this image and copyright information in PMC

Comment on

References

    1. Warburg O. Science. 1956;123:309–14. doi: 10.1126/science.123.3191.309. - DOI - PubMed
    1. Laplante M, et al. Cell. 2012;149:274–93. doi: 10.1016/j.cell.2012.03.017. - DOI - PMC - PubMed
    1. Tanaka K, et al. Cancer Discov. 2011;1:524–38. doi: 10.1158/2159-8290.CD-11-0124. - DOI - PMC - PubMed
    1. Masui K, et al. Cell Metab. 2013;18:726–39. doi: 10.1016/j.cmet.2013.09.013. - DOI - PMC - PubMed
    1. Dang CV, et al. Clin Cancer Res. 2009;15:6479–83. doi: 10.1158/1078-0432.CCR-09-0889. - DOI - PMC - PubMed

MeSH terms

Substances

LinkOut - more resources