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Comment
. 2014 Mar;85(3):494-5.
doi: 10.1038/ki.2013.389.

Acute kidney injury: a not-so-silent disease

Edward D Siew  1 , Susan L Furth  2
Affiliations
Comment

Acute kidney injury: a not-so-silent disease

Edward D Siew et al. Kidney Int. 2014 Mar.

Abstract

Hospitalized children are experiencing acute kidney injury (AKI) with increasing frequency and are especially vulnerable to its long-term complications. Attempts to leverage novel biomarkers to improve phenotyping of this disease are limited by untargeted testing within broadly selected populations. Here, we review efforts by Basu et al. to use readily available clinical information to identify critically ill children at higher risk for developing severe AKI, who may benefit from novel diagnostic and prognostic information.

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Figures

Figure
Figure. Improvements in Positive Predictive Value of a Hypothetical Biomarker Test with Increasing Disease Prevalence
A hypothetical example illustrating how a biomarker test with a sensitivity of 70% and specificity of 93% will have a positive predictive value of 54% if the prevalence of severe AKI is 10%. However, if the disease prevalence increases to 40% in patients with renal angina, the same test characteristics may improve positive predictive value to 88%.
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References

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