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Comment

. 2014 Mar;22(3):483-484.

doi: 10.1038/mt.2014.12.

A Hitchhiker's guide to the blood-brain barrier: in trans delivery of a therapeutic enzyme

Affiliations

PMID: 24584077
PMCID: PMC3944337
DOI: 10.1038/mt.2014.12

Comment

A Hitchhiker's guide to the blood-brain barrier: in trans delivery of a therapeutic enzyme

Mark S Sands. Mol Ther. 2014 Mar.

. 2014 Mar;22(3):483-484.

doi: 10.1038/mt.2014.12.

Author

Affiliation

¹ Departments of Internal Medicine and Genetics, Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address: msands@dom.wustl.edu.

PMID: 24584077
PMCID: PMC3944337
DOI: 10.1038/mt.2014.12

No abstract available

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Comment on

Effective intravenous therapy for neurodegenerative disease with a therapeutic enzyme and a peptide that mediates delivery to the brain.
Meng Y, Sohar I, Sleat DE, Richardson JR, Reuhl KR, Jenkins RB, Sarkar G, Lobel P. Meng Y, et al. Mol Ther. 2014 Mar;22(3):547-553. doi: 10.1038/mt.2013.267. Epub 2013 Dec 26. Mol Ther. 2014. PMID: 24394185 Free PMC article.

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References

1. Desnick RJ, Schuchman EH. Enzyme replacement therapy for lysosomal storage diseases: lessons from 20 years of experience and remaining challenges. Annu Rev Genomics Hum Genet. 2012;13:307–335. - PubMed
1. Meng Y, Sohar I, Sleat DE, Richardson JR, Reuhl KR, Jenkins RB.et al. (2014Effective intravenous therapy for neurodegenerative disease with a therapeutic enzyme and a peptide that mediates delivery to the brain Mol Ther 22547–553. - PMC - PubMed
1. Sarkar G, Curran GL, Mahlum E, Decklever T, Wengenack TM, Blahnik A.et al. (2011A carrier for non-covalent delivery of a functional beta-galactosidase and antibodies against amyloid plaques and IgM to the brain PLoS ONE 6e28881. - PMC - PubMed
1. Neufeld EF, Fratantoni JC. Inborn errors of mucopolysaccharide metabolism. Science. 1970;169:141–146. - PubMed
1. Achord DT, Brot CE, Bell E, Sly WS. Human beta-glucuronidase: in vivo clearance and in vitro uptake by a glycoprotein recognition system on reticuloendothelial cells. Cell. 1978;15:269–278. - PubMed

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