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Comment
. 2014 Mar;22(3):485-486.
doi: 10.1038/mt.2014.13.

From gut to brain: bioencapsulated therapeutic protein reduces amyloid load upon oral delivery

Imre Mäger  1 , Thomas C Roberts  2 , Matthew Ja Wood  3 , Samir El Andaloussi  4
Affiliations
Comment

From gut to brain: bioencapsulated therapeutic protein reduces amyloid load upon oral delivery

Imre Mäger et al. Mol Ther. 2014 Mar.
No abstract available

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Figures

Figure 1
Figure 1
Strategy for reducing amyloid plaques in the brain and retina upon oral administration of bioencapsulated CTB-MBP fusion protein. Cholera toxin B subunit (CTB) and myelin basic protein (MBP) fusion protein are expressed in chloroplasts to achieve their bioencapsulation. After lyophilization, the therapeutic compound is orally administered to triple-transgenic Alzheimer's disease (3×TgAD) mice. Following transmucosal uptake in gut and transcytosis across the blood–brain barrier (BBB) and blood–retinal barrier (BRB), MBP reduces amyloid plaques in the brain and retina.
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