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. 1988 Oct;62(10):3914-7.
doi: 10.1128/JVI.62.10.3914-3917.1988.

Inhibition of human immunodeficiency virus by using an oligonucleoside methylphosphonate targeted to the tat-3 gene

J A Zaia  1 , J J Rossi, G J Murakawa, P A Spallone, D A Stephens, B E Kaplan, R Eritja, R B Wallace, E M Cantin
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Inhibition of human immunodeficiency virus by using an oligonucleoside methylphosphonate targeted to the tat-3 gene

J A Zaia et al. J Virol. 1988 Oct.

Abstract

Antiviral effects were characterized for two oligodeoxyribonucleoside methylphosphonates synthesized in an antisense (3'-TCTTAACC-5') or a sense (5'-AGAATTGG-3') orientation, based on the RNA sequence of the first splice acceptor site of the tat-3 gene of human immunodeficiency virus (HIV) (5'...AGAAUUGG...3'). The development of syncytial cells and supernatant reverse transcriptase was inhibited by a single exposure to the antisense HIV, and HIV RNA synthesis was inhibited by both antisense and sense methylphosphonates but not by a control herpes simplex virus antisense sequence.

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