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Review
. 2014 Feb 21;20(7):1635-49.
doi: 10.3748/wjg.v20.i7.1635.

Treatment of gastric cancer

Michele Orditura  1 , Gennaro Galizia  1 , Vincenzo Sforza  1 , Valentina Gambardella  1 , Alessio Fabozzi  1 , Maria Maddalena Laterza  1 , Francesca Andreozzi  1 , Jole Ventriglia  1 , Beatrice Savastano  1 , Andrea Mabilia  1 , Eva Lieto  1 , Fortunato Ciardiello  1 , Ferdinando De Vita  1
Affiliations
Review

Treatment of gastric cancer

Michele Orditura et al. World J Gastroenterol. .

Abstract

The authors focused on the current surgical treatment of resectable gastric cancer, and significance of peri- and post-operative chemo or chemoradiation. Gastric cancer is the 4(th) most commonly diagnosed cancer and the second leading cause of cancer death worldwide. Surgery remains the only curative therapy, while perioperative and adjuvant chemotherapy, as well as chemoradiation, can improve outcome of resectable gastric cancer with extended lymph node dissection. More than half of radically resected gastric cancer patients relapse locally or with distant metastases, or receive the diagnosis of gastric cancer when tumor is disseminated; therefore, median survival rarely exceeds 12 mo, and 5-years survival is less than 10%. Cisplatin and fluoropyrimidine-based chemotherapy, with addition of trastuzumab in human epidermal growth factor receptor 2 positive patients, is the widely used treatment in stage IV patients fit for chemotherapy. Recent evidence supports the use of second-line chemotherapy after progression in patients with good performance status.

Keywords: Adjuvant chemotherapy; Chemoradiation; Gastric cancer; Palliative chemotherapy; Radiotherapy; Surgery.

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References

    1. Nashimoto A, Akazawa K, Isobe Y, Miyashiro I, Katai H, Kodera Y, Tsujitani S, Seto Y, Furukawa H, Oda I, et al. Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry. Gastric Cancer. 2013;16:1–27. - PMC - PubMed
    1. Choi MK, Kim GH, Park do Y, Song GA, Kim DU, Ryu DY, Lee BE, Cheong JH, Cho M. Long-term outcomes of endoscopic submucosal dissection for early gastric cancer: a single-center experience. Surg Endosc. 2013;27:4250–4258. - PubMed
    1. Cai J, Wei D, Gao CF, Zhang CS, Zhang H, Zhao T. A prospective randomized study comparing open versus laparoscopy-assisted D2 radical gastrectomy in advanced gastric cancer. Dig Surg. 2011;28:331–337. - PubMed
    1. Ahn HS, Lee HJ, Yoo MW, Jeong SH, Park DJ, Kim HH, Kim WH, Lee KU, Yang HK. Changes in clinicopathological features and survival after gastrectomy for gastric cancer over a 20-year period. Br J Surg. 2011;98:255–260. - PubMed
    1. Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2010 (ver. 3) Gastric Cancer. 2011;14:113–123. - PubMed

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