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Comparative Study
. 2014 Mar 3:22:16.
doi: 10.1186/1757-7241-22-16.

Interleukin-6 as inflammatory marker referring to multiple organ dysfunction syndrome in severely injured children

Hagen Andruszkow, Janika Fischer, Michael Sasse, Ulf Brunnemer, Julia Helga Karla Andruszkow, Axel Gänsslen, Frank Hildebrand, Michael Frink  1
Affiliations
Comparative Study

Interleukin-6 as inflammatory marker referring to multiple organ dysfunction syndrome in severely injured children

Hagen Andruszkow et al. Scand J Trauma Resusc Emerg Med. .

Abstract

Background: Despite the suggestion that the inflammatory response in traumatized children is functionally unique, prognostic markers predicting pediatric multiple organ failure are lacking. We intended to verify whether Interleukin-6 (IL-6) displays a pivotal role in pediatric trauma similar to adults.

Methods: Traumatized children less than 18 years of age with an Injury Severity Score >9 points and consecutive admission to the hospital's pediatric intensive care unit were included. Organ function was evaluated according to the score by Marshall et al. while IL-6 levels were measured repetitively every morning.

Results: 59 traumatized children were included (8.4 ± 4.4 years; 57.6% male gender). Incidence of MODS was 11.9%. No differences were found referring to age, gender, injury distribution or overall injury severity between children with and without MODS. Increased IL-6 levels during hospital admission were associated with injury severity (Spearman correlation: r = 0.522, p < 0.001), while an inconsistent association towards the development of MODS was proven at that time point (Spearman correlation: r = 0.180, p = 0.231; Pearson's correlation: r = 0.297, p = 0.045). However, increased IL-6 levels during the first two days were no longer associated with the injury severity but a significant correlation to MODS was measured.

Conclusions: The presented prospective study is the first providing evidence for a correlation of IL-6 levels with injury severity and the incidence of MODS in traumatized children.

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Figures

Figure 1
Figure 1
The course of IL-6 comparing children with and without MODS. Legend: abscissa: days. ordinate: IL-6 pg/ml. Significant differences were found at day 1 and 2 between the groups.
Figure 2
Figure 2
ROC-analysis of IL-6 towards MODS on the first three days.
See this image and copyright information in PMC

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