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Comment
. 2014 Apr;24(4):383-4.
doi: 10.1038/cr.2014.26. Epub 2014 Mar 4.

Bone's dark side: mutated osteoblasts implicated in leukemia

Amir Schajnovitz  1 , David T Scadden  1
Affiliations
Comment

Bone's dark side: mutated osteoblasts implicated in leukemia

Amir Schajnovitz et al. Cell Res. 2014 Apr.

Abstract

Bone-lining osteolineage cells were previously implicated as contributors to hematological disorders and malignancies. A recent report in Nature now demonstrates that a specific mutation in mouse collagen-expressing osteoblastic cells leads to MDS and AML with 100% penetrance and is associated with strikingly similar findings in human patients.

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Comment on

  • Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts.
    Kode A, Manavalan JS, Mosialou I, Bhagat G, Rathinam CV, Luo N, Khiabanian H, Lee A, Murty VV, Friedman R, Brum A, Park D, Galili N, Mukherjee S, Teruya-Feldstein J, Raza A, Rabadan R, Berman E, Kousteni S. Kode A, et al. Nature. 2014 Feb 13;506(7487):240-4. doi: 10.1038/nature12883. Epub 2014 Jan 15. Nature. 2014. PMID: 24429522 Free PMC article.

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