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Review
. 2014 Apr;1845(2):294-307.
doi: 10.1016/j.bbcan.2014.02.004. Epub 2014 Feb 28.

Pediatric low-grade gliomas: how modern biology reshapes the clinical field

Guillaume Bergthold  1 , Pratiti Bandopadhayay  2 , Wenya Linda Bi  1 , Lori Ramkissoon  3 , Charles Stiles  1 , Rosalind A Segal  4 , Rameen Beroukhim  1 , Keith L Ligon  3 , Jacques Grill  5 , Mark W Kieran  6
Affiliations
Review

Pediatric low-grade gliomas: how modern biology reshapes the clinical field

Guillaume Bergthold et al. Biochim Biophys Acta. 2014 Apr.

Abstract

Low-grade gliomas represent the most frequent brain tumors arising during childhood. They are characterized by a broad and heterogeneous group of tumors that are currently classified by the WHO according to their morphological appearance. Here we review the clinical features of these tumors, current therapeutic strategies and the recent discovery of genomic alterations characteristic to these tumors. We further explore how these recent biological findings stand to transform the treatment for these tumors and impact the diagnostic criteria for pediatric low-grade gliomas.

Keywords: BRAF; Genetics; Low-grade glioma; Pediatric.

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Figures

Figure 1
Figure 1
Comparison of the distribution of histological subtypes developping during childhood (0–19 years) and adulthood, according to the CBTRUS Statistical Report, 2012
Figure 2
Figure 2
Distribution of PLGGs histological subtypes during 4 stages of development, according to the CBTRUS Statistical Report, 2012
Figure 3
Figure 3
Targeted therapies currently in evaluation for PLGG treatment
See this image and copyright information in PMC

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