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. 2009 Dec 1;10(4):220-5.
eCollection 2009.

Comparison of two dosing regimens of vaginal misoprostol for labour induction: a randomised controlled trial

Shivarudraiah Girija  1 , Attibele Palaksha Manjunath  1
Affiliations

Comparison of two dosing regimens of vaginal misoprostol for labour induction: a randomised controlled trial

Shivarudraiah Girija et al. J Turk Ger Gynecol Assoc. .

Abstract
in English, Turkish

Objective: To compare the clinical efficacy of two different dosing regimens of vaginal misoprostol for labour induction.

Material and methods: This is an open label randomised controlled trial of 100 eligible women with obstetrical or medical indications for labour induction at a secondary level care hospital on the west coast of India. Women were randomised to receive either a single 50 μg dose or multiple 25 μg doses (maximum of three doses) of misoprostol in the posterior vaginal fornix. The main outcome measure was induction to vaginal delivery interval.

Results: Mean induction delivery interval was 18.58±13.73 and 14.42±13.2 hours (P=0.73) in the 50 μg and 25 μg misoprostol group respectively. Delivery rate within 24 hours were 60% (30/50), in 50 μg group and 68% (34/50) in 25 μg group (P=0.53). The rates of caesarean section and operative vaginal delivery were similar in both groups. There was no significant difference in maternal side effects and neonatal outcome among regimens.

Conclusion: There was no statistically significant difference between the two regimens in terms of clinical efficacy.

Amaç: Doğum indüksiyonunda iki farklı dozda vajinal misoprostol uygulamasının klinik etkinliğinin karşılaştırılması.

Gereç ve yöntemler: Bu açık uçlu rastgellenmiş çalışma Hindistanın batı bölgesinde ikinci basamak hizmet veren bir hastanede, doğum indüksiyonu için obstetrik veya tıbbi bir endikasyonu olan 100 gebede yapıldı. Kadınlara vajinal yoldan tek doz 50mcg veya en fazla 3 doz 25 mcg misoprostol uygulandı. Çalışmanın temel araştırma sonucu indüksiyondan doğuma kadar geçen süre idi.

Bulgular: İndüksiyondan doğuma kadar geçen süre 50 ve 25 mcg gruplarında sırasıyla 18.58±13.73 ve 14.42±13.2 saatti (p=0.73). 24 saat içinde doğum hızı 50 mcg grubunda %60 (30/50) ve 25 mcg grubunda %68 idi (p=0.53). Her iki gruptaki sezaryen ve operatif doğum oranları benzerdi. Her iki gruptaki maternal ve neonatal sonuçlar benzerdi.

Sonuç: Klinik etkinlik açısından her iki doz rejimleri arasında istatistiksel olarak anlamlı bir fark yoktu.

Keywords: Misoprostol; induction of labour; low dose; single dose.

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Figures

Figure 1
Figure 1
The consort E-flowchart for misoprostol trial
See this image and copyright information in PMC

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